US Labor Secretary Alex Acosta is resigning amid criticism of his brokering of a plea deal for financier Jeffrey Epstein in a child sex case.
Mr Acosta, a former Florida prosecutor, made the announcement from the White House Lawn on Friday, as President Donald Trump stood by his side.
Democrats had called for him to quit over his handling of the Epstein case.
Mr Acosta defended the plea deal in a press conference on Wednesday.
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